This model describes the effects of Il-21 on tumor eradication via natural killer cell-mediated and CD8+ T-cell-mediated lysis of tumor cells. The model demonstrates changes in growth dynamics in nonimmunogenic B16 melanoma and the immunogenic MethA and MCA205 fibrosarcomas, showing a strong dependence of the NK-cell/CD8+ T-cell balance on tumor immunogenicity.

 Sheriff Rahuman sheriff@ebi.ac.uk EMBL-EBI Meyer Johannes johannes.p.meyer@gmail.com EMBL-EBI 2019-07-08T14:34:54Z 2019-07-08T14:34:54Z 2019-07-08T14:34:54Z johannes.p.meyer@gmail.com Meyer Johannes EMBL-EBI sheriff@ebi.ac.uk Sheriff Rahuman EMBL-EBI v v 2019-07-09T15:33:09Z Z h h Z 3 2 2019-07-08T16:32:27Z X r1 r1 X 2019-07-08T16:32:29Z U a a U 2019-07-09T15:31:14Z M Y h2zero r2 sigma nD r2 Y 2 h2zero sigma M 1 M nD 2019-07-08T16:23:53Z b1 varU b2 b1 varU b2 varU 2019-07-08T16:32:28Z U X p1 p2 q1 r1 r1 X 2 p1 U p2 U q1 2019-07-08T16:40:12Z param1 mod1 mod2 sub1 param1 mod1 mod2 sub1 2019-07-08T16:32:26Z Y r2 r2 Y 2019-07-08T16:49:26Z varZ varZ 1 2 varZ 3 2 10 6 
No explicit compartment specified - paper implies that compartment encompasses entire organism.
 2019-07-10T10:59:51Z 
IL-21 concentration in the organism at any moment.
 2019-07-08T15:00:57Z 
Population dynamics of NK cells in the spleen.
 2019-07-08T15:01:17Z 
antitumor CD8+ T cells in the lymph nodes.
 2019-07-08T15:02:17Z 
CD8+ T Cell Memory Factor.
 2019-07-08T15:02:36Z 
Cytotoxic protein affecting tumor lysis.
 2019-07-08T15:02:47Z 
Tumor surface area at any moment.
 2019-07-08T15:03:00Z 2019-07-10T13:36:18Z 2019-07-10T13:37:08Z 2019-07-10T13:38:25Z 2019-07-10T13:36:36Z 2019-07-10T13:36:41Z 2019-07-10T13:38:31Z 2019-07-08T15:57:04Z 2019-07-10T13:42:19Z 2019-07-09T15:31:03Z 2019-07-10T13:38:48Z 2019-07-10T13:38:55Z 2019-07-10T13:36:44Z 2019-07-10T13:38:34Z 2019-07-10T13:41:30Z 2019-07-10T13:41:06Z 2019-07-10T13:41:05Z 2019-07-10T13:41:53Z 2019-07-10T13:36:17Z 2019-07-08T15:49:14Z compartment mu1 U 2019-07-08T15:50:15Z compartment Function_for_IL_21_Production_by_Tumor_1 Z h 2019-07-08T16:01:40Z compartment Function_for_NK_Cell_Population_Growth_1 X r1 2019-07-08T16:06:06Z compartment Function_for_NK_Cell_Population_Growth_IL_21_Inhibition_1 U X p1 p2 q1 r1 2019-07-08T16:11:12Z compartment Function_for_NK_Cell_Population_Growth_2 Y r2 2019-07-08T16:14:22Z compartment Function_for_CD8_Population_Growth_Inhibition_1 M Y h2zero r2 sigma D 2019-07-08T16:18:31Z compartment Function_for_NK_Cell_Population_Growth_3 U a 2019-07-08T16:19:41Z compartment mu2 M 2019-07-08T16:23:15Z compartment Function_for_Cytotoxic_Protein_Secretion b1 U b2 2019-07-08T16:26:29Z compartment mu3 P 2019-07-08T16:41:22Z compartment Function_for_Cytotoxic_Tumor_Killing k1 P X Z 2019-07-08T16:43:20Z compartment Function_for_Cytotoxic_Tumor_Killing k2 P Y Z 2019-07-08T16:47:55Z compartment Constant_flux__irreversible c 2019-07-08T16:49:16Z compartment Function_for_Tumor_Growth_Exponential Z